Science Jobs

Director, Preclinical Pharmacology (RNA/Oligo)

PHARMACOLOGY/TOXICOLOGY (SCIENCE)
  • Job ID: 19710
  • Direct Hire
  • MA
Email

Director, Preclinical Pharmacology (RNA/Oligo)
Location: Remote Boston-based

HireMinds is representing a client specializing in the siRNA, RNAi, & Oligonucleotide space that is using AI platform for the discovery of novel therapeutics. We are seeking to add your expertise in leading IND-enabling programs for this team. As the Director of Preclinical Development, you’ll lead a team in the design and execution of pharmacology and preclinical projects. Reporting to the Vice President, you’ll provide scientific and technical leadership to this team, ensuring projects meet strategic goals and regulatory standards. You’ll develop timelines and ensure studies, data, and findings are reported in efficient manner and under regulated standards in this exciting leadership role. 

You’ll Be Responsible For: 

  • Leading cross-functional teams in developing an in vivo strategy for efficient decision-making across the organization. 
  • Design preclinical programs with clear milestones, ensuring timelines are met.
  • Present project updates to the Executive Team and collaborate with internal stakeholders.
  • Manage partnerships with CROs to support data generation and regulatory needs.
  • Serve as an expert in targeted liver disease areas, adapting strategies based on competitive landscapes.
  • Develop Target Validation and refine biological readouts based on data insights.

You’ll Bring With You: 

  • PhD in biology, pharmacology, or related field, with expertise in translating in vivo models to human diseases.
  • 10+ years’ experience in drug discovery within pharma or biotech, focusing on in vivo pharmacology and preclinical models to progress successful drug candidate evaluations.
  • Proven ability to identify and validate in vivo models across disease areas including liver disease, blood disorders, ocular, and cardiovascular areas. 
  • Experience in managing CROs partnerships successfully through career examples. 
  • Commitment to ethical standards and regulatory compliance in data generation.
  • Project management and leadership skills with a drive for achieving project milestones.
  • Excellent communication skills for scientific reporting and regulatory documentation.
  • Proven success and experience with IND-enabling activities and regulatory submissions.
  • Experience with modalities including: siRNA, RNAi, RNA or oligonucleotide therapeutics.